Isn't direct measurement of serum B12 levels good enough? Why do we need indirect testing of Vitamin B12 deficiency through urine MMA levels?

Total serum B12 is not sufficiently sensitive or specific to be a reliable indicator of vitamin B12 deficiency as serum B12 level can be high although there is an actual deficiency of B12 available to the cells for proper physiological activity. Serum B12 levels are more appropriately considered to be an indicator of total body stores of vitamin B12

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• B12 Vitamin Deficiency Home Collection Urine Test Kit

Keywords: Vitamin B12

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