How do the testosterone gets lost in human body?

The loss of testosterone may be because of 3 general reasons. 1) The number and volume of leydig cells in the testicles decrease with age at about 1% per year after the age of 50 years. 2) Aging leads to loss of the LH pulse amplitude as well as a decreased response of LH to GnRH. 3) Increase in SHBG leads to a further decrease in free testosterone.

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