How does NicVAX act in our body?

NicVAX is administered via an injection into the arm; the 3'-aminomethylnicotine molecule found in the vaccine instigates an immune response in which anti-nicotine antibodies are created. The antibodies bind to nicotine molecules, causing the merged molecules to be too large to enter the brain; this prevents nicotine from being able to affect the body.

Overview of Addiction Treatment Effectiveness, Mim J. Landry- 1996

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