How CRP plays role in cardiovascular diseases?
It has been demonstrated that whenever there is any tissue damage or an injury to the inner lining of the arteries, which might also be due to free radical oxidation, CRPs migrate to these areas and together with the Low Density Lipoproteins (LDL), form fatty/wax-like substance (plaques) on these injured sites. This leads to hardening of the arteries and decrease in their diameter, impeding the blood flow. Over time, this narrowing prevents the blood from flowing properly through the arteries, giving rise to congestive heart failure, heart attack, or stroke. The CRP molecules also pump up the migration of White Blood Cells (WBCs) to these sites which break tiny portions of these plaques into the bloodstream. These small fragments of plaque can then be swept away to lodge in small blood vessels in the heart or brain, causing an increase in the frequency of heart attack or stroke.
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